Development of nanoparticles with self-regulating magnetic hyperthermia properties for oncology treatment
In recent years, a method of solid-phase pyrolysis of phthalocyanines has been developed by the Laboratory of Solid State Physics at IPR-NAS. This method provides a possibility to synthesize а number of metal-carbon nanocomposites and binary metal nanoalloys. In particular, it is possible to prepare both ferromagnetic (Ni, Co, Fe) and superparamagnetic nanoparticles in different carbon matrices. Some of these materials can be proposed for application in medicine, e.g., for self-regulating magnetic hyperthermia in oncology and as contrast-agents in magnetic resonance imaging. In particular, recently the ferromagnetic carbon-coated Ni1-xCux nanoalloys with a Curie temperature in the range of 42-47oC were synthesized, which can be suitable for self-regulating magnetic hyperthermia.
Magnetic hyperthermia works on the principle that magnetic nanoparticles produce heat when subjected to an alternating magnetic field. The nanoparticles are injected into the blood stream and circulate in the dense blood vessels surrounding a tumour. By then subjecting the patient’s tumour to a localised magnetic field of specific amplitude and frequency, the tumour can be heated up and destroyed.
To facilitate the transfer of the technology and associated knowledge to the healthcare sector, IPR-NAS need LZH to educate and train them on i) how to measure the structural and magnetic characteristics of ferromagnetic and superparamagnetic (Ni – Cu)/C nanocomposites with Curie temperatures in the range of 42-47oC and ii) how to test the best samples in self- regulating magnetic hyperthermia.